Vemurafenib + Tizanidine Interaction
Majorinteraction on record
Description
CYP1A2 substrate with narrow therapeutic window. Vemurafenib increased tizanidine systemic exposure by 4.7-fold. Avoid concomitant use or monitor closely for toxicities and consider dose reduction.
Mechanism
CYP1A2 inhibition
Source: NLP:vemurafenib