Vanzacaftor Tezacaftor And Deutivacaftor + Mao Inhibitors Interaction
Majorinteraction on record
Description
Reduce ALYFTREK dosage with concomitant use. CYP3A inhibitors increase vanzacaftor, tezacaftor, and deutivacaftor exposure, which may increase risk of adverse reactions.
Mechanism
CYP3A inhibition increases substrate exposure
Source: NLP:vanzacaftor, tezacaftor, and deutivacaftor