Valproic Acid + Imipenem Anhydrous Cilastatin And Relebactam Anhydrous Interaction
Majorinteraction on record
Description
May decrease valproic acid concentrations, increasing risk of breakthrough seizures. Concomitant use should be avoided.
Mechanism
Carbapenems may inhibit hydrolysis of valproic acid's glucuronide metabolite back to valproic acid, decreasing serum concentrations
Source: NLP:imipenem anhydrous, cilastatin, and relebactam anhydrous