Valproate + Pivmecillinam Interaction

Majorinteraction on record

Description

Concurrent use may decrease carnitine concentrations and increase risk of carnitine depletion-associated adverse reactions including hypoglycemia, muscle aches, fatigue, and confusion.

Mechanism

Both are pivalate-generating drugs; pivalate metabolism decreases plasma carnitine concentrations

Source: NLP:pivmecillinam