Valproate + Lamotrigine Interaction
Majorinteraction on record
Description
Valproate increases lamotrigine concentrations more than 2-fold, requiring dose adjustment.
Mechanism
Inhibits lamotrigine glucuronidation
Source: NLP:lamotrigine
Valproate increases lamotrigine concentrations more than 2-fold, requiring dose adjustment.
Inhibits lamotrigine glucuronidation
Source: NLP:lamotrigine