Valoctocogene Roxaparvovec Rvox + Isotretinoin Interaction
Majorinteraction on record
Description
Decreased factor VIII activity without ALT elevation detected after starting isotretinoin. Factor VIII activity transiently decreased to <3 IU/dL after initiation and recovered after discontinuation. In vitro studies show isotretinoin suppresses factor VIII transcription.
Mechanism
Isotretinoin suppresses factor VIII transcription independent of hepatotoxicity
Source: NLP:valoctocogene roxaparvovec-rvox