Umeclidinium Bromide And Vilanterol Trifenatate + Nonselective Beta Adrenergic Antagonists Interaction
Majorinteraction on record
Description
May block bronchodilatory effects of vilanterol and produce severe bronchospasm in COPD patients. Avoid use; if necessary, use cardioselective beta-blockers with caution.
Mechanism
Beta-adrenergic receptor blockade antagonizes beta-agonist bronchodilation
Source: NLP:umeclidinium bromide and vilanterol trifenatate