Trimethoprim + Spironolactone Interaction
Majorinteraction on record
Description
Trimethoprim can increase serum potassium; concomitant use with spironolactone may lead to severe hyperkalemia.
Mechanism
Potassium elevation
Source: NLP:spironolactone
Trimethoprim can increase serum potassium; concomitant use with spironolactone may lead to severe hyperkalemia.
Potassium elevation
Source: NLP:spironolactone