Triamterene + Dofetilide Interaction

Contraindicatedinteraction on record

Description

Triamterene in combination with HCTZ increases dofetilide AUC by 30%, Cmax by 16%, with pharmacodynamic effects increased by 190% (QTc increase over time). Concomitant use is contraindicated.

Mechanism

Increased exposure and potassium effects

Source: NLP:dofetilide