Tramadolapap + Mao Inhibitors Interaction
Majorinteraction on record
Description
Concomitant use may increase tramadol plasma concentration and increase M1 levels, resulting in seizures, serotonin syndrome, and potentially fatal respiratory depression.
Mechanism
CYP3A4 inhibition increasing tramadol exposure and metabolism via CYP2D6 to M1
Source: NLP:tramadol/apap