Tramadolapap + Bupropion Interaction
Majorinteraction on record
Description
CYP2D6 inhibitor may increase tramadol plasma concentration and decrease M1 concentration, resulting in increased risk of seizures, serotonin syndrome, and opioid withdrawal or toxicity.
Mechanism
CYP2D6 inhibition decreasing M1 formation and increasing tramadol exposure
Source: NLP:tramadol/apap