Topiramate + Sitagliptin And Metformin Hydrochloride Interaction

Majorinteraction on record

Description

Carbonic anhydrase inhibitor that decreases serum bicarbonate and induces metabolic acidosis, increasing risk for lactic acidosis when used with JANUMET.

Mechanism

Decreases serum bicarbonate and induces non-anion gap, hyperchloremic metabolic acidosis

Source: NLP:sitagliptin and metformin hydrochloride