Thyroid + Oral Anticoagulants Interaction
Majorinteraction on record
Description
Thyroid hormones increase catabolism of vitamin K-dependent clotting factors, impairing compensatory increases in clotting factor synthesis. Patients stabilized on oral anticoagulants starting thyroid replacement require close monitoring and likely need anticoagulant dose reduction.
Mechanism
Increased catabolism of vitamin K-dependent clotting factors
Source: NLP:thyroid, unspecified