Temsirolimus + Rifampin Interaction

Moderateinteraction on record

Description

Potent CYP3A4/5 inducer decreases sirolimus (primary metabolite) Cmax by 65% and AUC by 56%. Dose adjustment of temsirolimus recommended if alternative cannot be used.

Mechanism

CYP3A4/5 induction

Source: NLP:temsirolimus