Sulfamethoxazole And Trimethoprim + Leucovorin Calcium Interaction
Contraindicatedinteraction on record
Description
Avoid concomitant use. Leucovorin decreases effectiveness of trimethoprim-sulfamethoxazole, associated with increased treatment failure and mortality in HIV patients with Pneumocystis jirovecii pneumonia.
Mechanism
Leucovorin reduces the effectiveness of trimethoprim-sulfamethoxazole
Source: NLP:leucovorin calcium