Sulfamethoxazole And Trimethoprim + Dapsone Interaction
Moderateinteraction on record
Description
TMP/SMX increases systemic levels of dapsone and its metabolites (AUC increased ~40% for dapsone, ~20% for N-acetyldapsone, >100% for dapsone hydroxylamine). Monitor for increased dapsone exposure and potential toxicity.
Mechanism
Inhibition of dapsone metabolism
Source: NLP:dapsone