Strong Or Moderate Cyp3a Inducers + Vanzacaftor Tezacaftor And Deutivacaftor Interaction
Majorinteraction on record
Description
Concomitant use is not recommended. CYP3A inducers decrease vanzacaftor, tezacaftor, and deutivacaftor exposure, which may reduce ALYFTREK effectiveness.
Mechanism
CYP3A induction decreases substrate exposure
Source: NLP:vanzacaftor, tezacaftor, and deutivacaftor