Stiripentol + Clobazam Interaction

Moderateinteraction on record

Description

DIACOMIT increases plasma concentration of clobazam and its active metabolite norclobazam through inhibition of CYP3A4 and CYP2C19, increasing risk of adverse reactions. Consider dose reduction of clobazam.

Mechanism

Inhibition of CYP3A4 and CYP2C19

Source: NLP:stiripentol