St Johns Wort + Norethindrone Acetateethinyl Estradiol Interaction
Majorinteraction on record
Description
St. John's Wort may induce hepatic enzymes and p-glycoprotein transporter, reducing contraceptive effectiveness and increasing breakthrough bleeding.
Mechanism
Induction of cytochrome P450 and p-glycoprotein transporter
Source: NLP:norethindrone acetate and ethinyl estradiol