Spironolactone And Hydrochlorothiazide + Digoxin Interaction
Majorinteraction on record
Description
Spironolactone increases digoxin half-life, leading to increased serum levels and potential digitalis toxicity; electrolyte disturbances increase toxicity risk.
Mechanism
Increased digoxin half-life
Source: NLP:spironolactone and hydrochlorothiazide