Sofosbuvir Velpatasvir And Voxilaprevir + St Johns Wort Interaction
Majorinteraction on record
Description
P-gp inducer and moderate to strong CYP inducer that may significantly decrease plasma concentrations of sofosbuvir, velpatasvir, and/or voxilaprevir, leading to reduced therapeutic effect.
Mechanism
P-gp induction and CYP2B6, CYP2C8, CYP3A4 induction
Source: NLP:sofosbuvir, velpatasvir, and voxilaprevir