Sodium Bicarbonate + Memantine Hydrochloride And Donepezil Hydrochloride Interaction

Moderateinteraction on record

Description

Sodium bicarbonate may alter urine pH towards alkaline conditions, reducing memantine clearance by about 80% and leading to drug accumulation.

Mechanism

Alkaline urine reduces memantine clearance

Source: NLP:memantine hydrochloride and donepezil hydrochloride

Related drug profiles

All Sodium Bicarbonate interactions →All Memantine Hydrochloride And Donepezil Hydrochloride interactions →
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