Sensitive Cyp3a Substrates + Nitisinone Interaction

Majorinteraction on record

Description

Nitisinone is a moderate CYP2C9 inhibitor that may increase exposure of co-administered drugs metabolized by CYP2C9, requiring dosage reduction by half and additional adjustments to maintain therapeutic concentrations.

Mechanism

CYP2C9 inhibition

Source: NLP:nitisinone