Sensitive Cyp3a Substrates + Givinostat Interaction
Majorinteraction on record
Description
Givinostat is a weak intestinal CYP3A4 inhibitor. Closely monitor when used with oral CYP3A4 sensitive substrates where small changes in plasma concentration may lead to serious toxicities.
Mechanism
CYP3A4 inhibition
Source: NLP:givinostat