Selective Serotonin Reuptake Inhibitors Ssri + Palonosetron Hydrochloride Interaction

Majorinteraction on record

Description

Concomitant use may cause serotonin syndrome including altered mental status, autonomic instability, and neuromuscular symptoms. Monitor for emergence and discontinue palonosetron if symptoms occur.

Mechanism

Additive serotonergic effects via 5-HT3 receptor antagonism and serotonin reuptake inhibition

Source: NLP:palonosetron hydrochloride