Saxagliptin And Metformin Hydrochloride + Topiramate Interaction

Majorinteraction on record

Description

Carbonic anhydrase inhibitor causing metabolic acidosis. Concomitant use may increase risk of metformin-associated lactic acidosis.

Mechanism

Decreases serum bicarbonate, induces metabolic acidosis

Source: NLP:saxagliptin and metformin