Saxagliptin And Metformin Hydrochloride + Cimetidine Interaction
Majorinteraction on record
Description
OCT2/MATE inhibitor that reduces metformin clearance, increasing systemic exposure and risk for lactic acidosis.
Mechanism
Inhibits organic cationic transporter-2 (OCT2) and MATE renal transport
Source: NLP:saxagliptin and metformin