Sapropterin Dihydrochloride + Valproic Acid Interaction

Moderateinteraction on record

Description

May decrease endogenous BH4 levels by inhibiting dihydrofolate reductase, potentially increasing phenylalanine levels.

Mechanism

Inhibition of dihydrofolate reductase, reducing BH4 recycling

Source: NLP:sapropterin dihydrochloride