Rufinamide + Phenytoin Interaction
Moderateinteraction on record
Description
Phenytoin decreases rufinamide concentration by 25-46% and rufinamide increases phenytoin by 7-21% with potential for greater exposure due to phenytoin's non-linear pharmacokinetics.
Mechanism
Phenytoin induces rufinamide clearance; rufinamide decreases phenytoin clearance
Source: NLP:rufinamide