Rifabutin + Ketoconazole Interaction
Majorinteraction on record
Description
Potent CYP3A4 enzyme inducer that may decrease ketoconazole bioavailability and reduce antifungal efficacy. Coadministration not recommended.
Mechanism
CYP3A4 induction decreases ketoconazole bioavailability
Source: NLP:ketoconazole