Ranolazine + Sitagliptin And Metformin Hydrochloride Interaction

Majorinteraction on record

Description

Inhibits metformin renal clearance via OCT2/MATE transporter interference, increasing systemic metformin exposure and lactic acidosis risk.

Mechanism

Organic cationic transporter-2 (OCT2)/multidrug and toxin extrusion (MATE) inhibitor

Source: NLP:sitagliptin and metformin hydrochloride

Related drug profiles

All Ranolazine interactions →All Sitagliptin And Metformin Hydrochloride interactions →
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