Ranolazine + Pioglitazole And Metformin Hydrochloride Interaction

Majorinteraction on record

Description

OCT2/MATE inhibitor reduces metformin clearance, increasing systemic exposure and risk for lactic acidosis. Consider benefits and risks of concomitant use.

Mechanism

Inhibits renal tubular transport of metformin (OCT2/MATE)

Source: NLP:pioglitazone hydrochloride and metformin hydrochloride