Rabeprazole Sodium + Methotrexate Interaction
Majorinteraction on record
Description
Concomitant use may elevate and prolong serum levels of methotrexate and its metabolite hydroxymethotrexate, possibly leading to methotrexate toxicities.
Mechanism
Impaired clearance of methotrexate and metabolites
Source: NLP:rabeprazole sodium