Quinidine + Tetrabenazine Interaction

Majorinteraction on record

Description

Strong CYP2D6 inhibitor that markedly increases exposure to tetrabenazine metabolites. Dose reduction necessary; maximum daily dose 50 mg, maximum single dose 25 mg.

Mechanism

CYP2D6 inhibition increases α-HTBZ and β-HTBZ metabolite exposure

Source: NLP:tetrabenazine