Propafenone + Bupropion Hydrobromide Interaction

Moderateinteraction on record

Description

CYP2D6 substrate Type 1C antiarrhythmic. Bupropion inhibits CYP2D6 and can increase propafenone concentrations. Consider dose reduction of propafenone when used with bupropion.

Mechanism

CYP2D6 inhibition

Source: NLP:bupropion hydrobromide