Promethazine Phenylephrine Codeine + Erythromycin Interaction

Majorinteraction on record

Description

CYP3A4 inhibitor may increase codeine plasma concentrations and morphine levels, potentially causing fatal respiratory depression.

Mechanism

CYP3A4 inhibition leading to increased codeine/morphine metabolism

Source: NLP:promethazine, phenylephrine, codeine