Promethazine Hydrochloride And Dextromethorphan Hydrobromide + Opioid Analgesics Interaction

Majorinteraction on record

Description

Promethazine may increase, prolong, or intensify sedative action. Dose reduction recommended when given concomitantly.

Mechanism

Additive CNS depression

Source: NLP:promethazine hydrochloride and dextromethorphan hydrobromide