Pirfenidone Capsule 267 Mg + Fluvoxamine Interaction

Majorinteraction on record

Description

Strong CYP1A2 inhibitor significantly increases pirfenidone exposure. Concomitant use is not recommended; discontinue fluvoxamine prior to pirfenidone administration or reduce pirfenidone to 267 mg three times daily.

Mechanism

CYP1A2 inhibition

Source: NLP:pirfenidone capsule, 267 mg