Phenytoin + Levoleucovorin Calcium Interaction
Moderateinteraction on record
Description
Folic acid in large amounts may counteract the antiepileptic effect and increase seizure frequency in susceptible children. Unclear if folinic acid has same effects, but they share metabolic pathways. Monitor patients.
Mechanism
Folic/folinic acid may counteract antiepileptic effect through shared metabolic pathways
Source: NLP:levoleucovorin calcium