Phentermine And Topiramate Extended Release + Norethindrone And Ethinyl Estradiol Interaction
Moderateinteraction on record
Description
Co-administration decreases ethinyl estradiol exposure by 16% and increases norethindrone exposure by 22%, potentially causing irregular bleeding/spotting due to altered hormone balance.
Mechanism
Altered pharmacokinetics of oral contraceptive components
Source: NLP:phentermine and topiramate extended-release