Phentermine And Topiramate + Norethindrone And Ethinyl Estradiol Interaction
Moderateinteraction on record
Description
Co-administration decreased ethinyl estradiol exposure by 16% and increased norethindrone exposure by 22%, potentially causing irregular bleeding/spotting.
Mechanism
Altered pharmacokinetics of oral contraceptive components
Source: NLP:phentermine and topiramate