Perphenazine And Amitriptyline Hydrochloride + Fluoxetine Interaction
Majorinteraction on record
Description
Fluoxetine inhibits cytochrome P450 2D6 and has a long half-life; at least 5 weeks must elapse before initiating amitriptyline after fluoxetine withdrawal.
Mechanism
Inhibition of cytochrome P450 2D6
Source: NLP:perphenazine and amitriptyline hydrochloride