Perphenazine And Amitriptyline Hydrochloride + Cimetidine Interaction
Majorinteraction on record
Description
Cimetidine inhibits cytochrome P450 2D6, potentially causing toxic amitriptyline concentrations; dose reduction may be necessary.
Mechanism
Inhibition of cytochrome P450 2D6
Source: NLP:perphenazine and amitriptyline hydrochloride