Pemetrexed Dipotassium + Ibuprofen Interaction
Majorinteraction on record
Description
Ibuprofen increases pemetrexed AUC and toxicity risk, especially in patients with mild to moderate renal impairment (CrCl 45-79 mL/min). Avoid ibuprofen for 2 days before, day of, and 2 days after pemetrexed administration.
Mechanism
Increased pemetrexed exposure (AUC)
Source: NLP:pemetrexed dipotassium