Paroxetine Hydrochloride Hemihydrate + Pimozide Interaction
Contraindicatedinteraction on record
Description
Paroxetine increases pimozide AUC by 151% and Cmax by 62%, leading to increased QT prolongation risk. Contraindicated due to narrow therapeutic index.
Mechanism
CYP2D6 inhibition by paroxetine
Source: NLP:paroxetine hydrochloride hemihydrate