Pantoprazole Sodium In 09 Sodium Chloride + Methotrexate Interaction
Majorinteraction on record
Description
Concomitant use of pantoprazole with methotrexate (primarily at high dose) may elevate and prolong serum concentrations, possibly leading to methotrexate toxicities.
Mechanism
PPIs elevate and prolong methotrexate and hydroxymethotrexate concentrations
Source: NLP:pantoprazole sodium in 0.9% sodium chloride