Pantoprazole Sodium Granules + Methotrexate Interaction
Majorinteraction on record
Description
Concomitant use may elevate and prolong serum concentrations of methotrexate and hydroxymethotrexate, possibly leading to toxicities, especially at high doses.
Mechanism
PPI may reduce renal clearance of methotrexate
Source: NLP:pantoprazole sodium granules