Pantoprazole Sodium Delayed Release + Methotrexate Interaction
Majorinteraction on record
Description
Concomitant use of pantoprazole with methotrexate (primarily at high dose) may elevate and prolong serum concentrations of methotrexate and metabolite, possibly leading to toxicities.
Mechanism
Elevated and prolonged serum concentrations; mechanism not specified
Source: NLP:pantoprazole sodium delayed-release