Pantoprazole Sodium + Methotrexate Interaction
Majorinteraction on record
Description
Concomitant use may elevate and prolong serum concentrations of methotrexate and/or hydroxymethotrexate, possibly leading to methotrexate toxicities, particularly at high doses.
Mechanism
Elevated and prolonged methotrexate serum concentrations
Source: NLP:pantoprazole sodium injection