P Gp Or Bcrp Substrates + Vanzacaftor Tezacaftor And Deutivacaftor Interaction
Moderateinteraction on record
Description
Monitor more frequently for adverse reactions. Tezacaftor and deutivacaftor are P-gp inhibitors that increase exposure of P-gp substrates.
Mechanism
P-glycoprotein inhibition increases substrate exposure
Source: NLP:vanzacaftor, tezacaftor, and deutivacaftor